Tachyphylaxis to PACAP-27 after inhibition of NO synthesis: a loss of adenylate cyclase activation.

Autor: Whalen, Erin J., Johnson, Alan Kim
Předmět:
Zdroj: American Journal of Physiology: Regulatory, Integrative & Comparative Physiology; Nov99, Vol. 46 Issue 5, pR1453, 9p, 3 Charts, 5 Graphs
Abstrakt: Focuses on a study which determined tachyphylaxis to pituitary adenylate cyclase activating polypeptide (PACAP-27) in N-nitro-L-arginine methyl ester (L-NAME)-treated rats. Hemodynamic effects of five successive injections of PACAP-27 in saline- or L-NAME-treated rats; Baseline hemodynamic values in saline-treated rats that received five successive injections of PACAP-27; Resting hemodynamic parameters before injections of saline or PACAP-27.
Databáze: Complementary Index