| Autor: |
Tao Zou, Song-Lin Li, Zhao-Yu Hu, Si-Xue Cheng, Ren-Xi Zhuo |
| Předmět: |
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| Zdroj: |
Journal of Biomaterials Science -- Polymer Edition; May2007, Vol. 18 Issue 5, p519-530, 12p, 1 Diagram, 1 Chart, 2 Graphs |
| Abstrakt: |
Star oligo/poly(trimethylene carbonate)s with cholic acid moieties as cores were synthesized by ring-opening polymerization of trimethylene carbonate (TMC) initiated by cholic acid with hydroxyl groups. The molecular weights of the star oligomers/polymers were controlled by adjusting the feed ratio of the initiator cholic acid to the monomer TMC. The star oligo/poly(trimethylene carbonate)s were characterized by Fourier transform infrared spectroscopy (FT-IR), 1H nuclear magnetic resonance spectroscopy (1H-NMR) and combined size-exclusion chromatography and multiangle laser light scattering (SEC-MALLS) analysis. The water contact angles of the star oligo/poly(trimethylene carbonate)s were measured. Using 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, the star oligo/poly(trimethylene carbonate) was proved to have a low cytotoxicity. A microsphere drug-delivery system based on a star polymer was fabricated and its in vitro drug release property was studied. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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