| Autor: |
SHPAKOV, ALEXANDER, PERTSEVA, MARIANNA, KUZNETSOVA, LUDMILA, PLESNEVA, SVETLANA |
| Předmět: |
|
| Zdroj: |
Annals of the New York Academy of Sciences; 2005, Vol. 1041 Issue 1, p305-307, 3p |
| Abstrakt: |
For the first time, the adenylate cyclase signaling mechanism (ACSM) of the action of relaxin H2 was revealed and deciphered in human and rat muscle tissues. The comparative study of signaling blocks forming the ACSM of relaxin and insulin (discovered earlier) showed that the postreceptor signaling chain of relaxin coincides with that of insulin. However, the type of relaxin receptor involved in ACSM remains obscure. Currently, the ACSM of relaxin may be represented as a signaling cascade: receptor ⇒ Gi protein (βγ-dimer) ⇒ phosphatidylinositol 3-kinase (PI3K) ⇒ protein kinase Cζ (PKCζ) ⇒ Gs protein ⇒ adenylate cyclase. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text