| Autor: |
SIEBEL, ANDREW L., GEHRING, HELEN M., VODSTRCIL, LENKA, PARRY, LAURA J. |
| Předmět: |
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| Zdroj: |
Annals of the New York Academy of Sciences; 2005, Vol. 1041 Issue 1, p104-109, 6p |
| Abstrakt: |
Relaxin decreases oxytocin-stimulated rat myometrial contractions in vitro. This study used pregnant relaxin-deficient (Rlx-/-) mice to investigate the interaction between relaxin, oxytocin receptor (OTR), and estrogen receptor (ER) expression in the myometrium. Myometrial OTRs were significantly decreased on gestation day 18.5 in Rlx-/- mice than in Rlx+/+ mice. An increase in ER in Rlx+/+ mice at term was correlated with a decrease in ER, which was not observed in Rlx-/- mice. Treatment of Rlx-/- mice with relaxin had no effect on OTR, LGR7, or ER expression, but it caused a significant decrease in ERs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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