| Autor: |
SCHWEINSBURG, ALECIA D., PAULUS, MARTIN P., BARLETT, VALERIE C., KILLEEN, LAUREN A., CALDWELL, LISA C., PULIDO, CARMEN, BROWN, SANDRA A., TAPERT, SUSAN F. |
| Předmět: |
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| Zdroj: |
Annals of the New York Academy of Sciences; 2004, Vol. 1021 Issue 1, p391-394, 4p |
| Abstrakt: |
Disinhibition among alcoholics may precede or result from alcohol use disorders (AUDs). It remains unclear how disinhibition might contribute to AUD risk among youths with a family history of alcoholism (FLIP). We used functional magnetic resonance imaging (fMRI) to explore inhibition-related neural risk factors for AUD. Participants were 12- to14-year-old nondrinkers, including 12 FHP youths and 14 youths with no family history of alcoholism (FHN). Youths performed a go/no-go task during fMRI acquisition. At a conservative threshold, FHN youths showed less inhibitory response than FLIP youths in the left middle frontal gyms, despite similar task performance between groups. Using a more liberal threshold, FLIP youths also demonstrated less response in additional frontal regions. These preliminary findings suggest that FLIP youths show less inhibitory frontal response than FHN youths. Altered neural activation among FLIP youths may underlie subsequent disinhibition and could be related to the AUD risk. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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