| Abstrakt: |
Multiple determinants are involved in the progression of human papillomavirus (HPV)âinfected cervical lesion to invasive cancer. Human leukocyte antigen (HLA) polymorphism seems to play a role. This study examined the association between HLAâDRB1 polymorphism, highârisk HPV infection, and the development of cervical neoplasia in southern Chinese. Three hundred and seventy women with cervical neoplasia (43 cervical intraepithelial neoplasia grade II, 154 grade III, and 173 invasive cancers) and 323 controls were recruited for HLAâDRB1 typing by a sequenceâbased approach. Cervical specimens were collected for HPV detection by a consensus primerâbased polymerase chain reaction, and with the type of HPV identified by hybridization with typeâspecific oligonucleotide probes. A protective effect of HLAâDRB1*12 for cervical neoplasia was observed, and with stronger associations when subgroup analyses were carried out for patients infected with HPV16 and HPV58. The protective effect of HLAâDRB1*13 that had been reported from other populations was not observed. The data obtained in this study showed that HLAâDRB1*03 conferred a higher risk for HPV18âinfected, but not for HPV16â, HPV52â, or HPV58âinfected cervical lesions. Although, HPV52 was reported as uncommon worldwide, it was found to be the second most prevalent type in the southern Chinese population. However, no additional risk association was observed when subgroup analyses were performed for HPV52âinfected patients. The current study shows that, among southern Chinese, the outcome of HPVâinfected cervical lesions is associated with HLAâDRB1 polymorphism. These associations often vary with the type of HPV infection. J. Med. Virol. 79:970â976, 2007. © 2007 WileyâLiss, Inc. [ABSTRACT FROM AUTHOR] |
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