| Autor: |
Y. Ahmad, J. Shelmerdine, H. Bodill, M. Lunt, M. G. Pattrick, L. S. Teh, R. M. Bernstein, M. G. Walker, I. N. Bruce |
| Předmět: |
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| Zdroj: |
Rheumatology; May2007, Vol. 46 Issue 6, p983-983, 1p |
| Abstrakt: |
Objectives. We aimed to examine the strength of association between traditional cardiovascular risk factors and carotid plaque development in systemic lupus erythematosus (SLE) patients and controls. We also aimed to determine which lupus-related factors are associated with carotid plaque and whether SLE sensitizes patients to the effects of traditional factors. Methods. We studied 200 women with SLE and 100 controls. Demographic and risk factor data were collected and SLE features, including autoantibody profiles and therapy were noted. All subjects had B- mode ultrasound of their carotid arteries examined for the presence and distribution of plaque. Results. SLE patients vs 3% Pâvs 4%; Pâvs 0.90; PâPâConclusions. SLE patients have a higher prevalence and different distribution of carotid plaque than controls. SLE factors perform significantly better than traditional risk factors in their association with atherosclerosis in SLE and these factors add to the influence of traditional risk factors rather than sensitizing lupus patients to traditional factors. The SLE phenotype helps identify patients at increased risk of atherosclerosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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