Effect of classic convulsants on Cl− conductance of the GABAA receptor complex in membranes of cerebral cortex cells at the early stage of kindling.

Autor:	I. Rebrov, M. Karpova, A. Andreev, M. Kalinina, N. Klishina, L. Kuznetsova
Předmět:	PICROTOXIN IONOPHORES GABA AMINO acid neurotransmitters
Zdroj:	Bulletin of Experimental Biology & Medicine; Jan2007, Vol. 143 Issue 1, p12-14, 3p
Abstrakt:	Abstract  Muscimol-stimulated Cl− conductance of synaptoneurosomes from the cerebral cortex of Wistar rats increased during the early stage of pharmacological kindling not inducing the seizure response in animals. Picrotoxin, bicuculline, and pentylenetetrazole potentiated inhibition of muscimol-dependent 36Cl− entry into synaptoneurosomes, which attested to increased sensitivity of the GABAA receptor/Cl− ionophore complex to classic convulsants. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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