In vivo occupancy of striatal and temporal cortical D2/D3 dopamine receptors by typical antipsychotic drugs. [123I]epidepride single photon emission tomography (SPET) study.

Autor:	Bigliani, Valeria, Mulligan, Rachel S., Acton, Paul D., Visvikis, Dimitris, Ell, Peter J., Stephenson, Caroline, Kerwin, Robert W., Pilowsky, Lyn S., Bigliani, V, Mulligan, R S, Acton, P D, Visvikis, D, Ell, P J, Stephenson, C, Kerwin, R W, Pilowsky, L S
Předmět:	DOPAMINE ANTIPSYCHOTIC agents MENTAL illness treatment PEOPLE with schizophrenia SCHIZOPHRENIA CHLORPROMAZINE DRUG therapy for schizophrenia BENZAMIDE CELL receptors COMPARATIVE studies HETEROCYCLIC compounds RESEARCH methodology MEDICAL cooperation RESEARCH TEMPORAL lobe POSITRON emission tomography EVALUATION research IODINE radioisotopes
Zdroj:	British Journal of Psychiatry; Sep99, Vol. 175, p231-238, 8p
Abstrakt:	Background: The dopamine hypothesis proposes that antipsychotic drugs act primarily through limbic cortical D2/D2-like dopamine receptor blockade.Aim: To evaluate this hypothesis with the D2/D3-selective SPET probe [123I]-epidepride.Method: [123I]-epidepride SPET scans were performed on 12 patients with schizophrenia treated with antipsychotics and II age-matched healthy controls. [123I]-epidepride 'specific binding' to D2/D3 dopamine receptors was estimated, and relative percentage D2/D3 receptor occupancy by typical antipsychotic drugs determined.Results: Mean (s.d.) daily dose was 669.12 (516.8) mg chlorpromazine equivalents. Mean percentage D2/D3 receptor occupancy was 81.6 (8.1) and 73.2 (13.9) in the temporal cortex and striatum respectively.Conclusions: Typical antipsychotic drug treatment is associated with substantial temporal cortical D2/D3 receptor occupancy. The relationship between this and efficacy is poor in patients with treatment-resistant schizophrenia. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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