Synthesis and anticancer properties of 7α-chloro-3-methyl-1,1-dioxoceph-3-em-4-carboxylic acid esters.

Autor: Vorona, M., Veinberg, G., Shestakova, I., Kanepe, I., Potorochina, I., Dikovskaya, K., Bokaldere, R., Petrova, M., Liepinsh, E., Lukevics, E.
Předmět:
Zdroj: Chemistry of Heterocyclic Compounds; Feb2007, Vol. 43 Issue 2, p207-219, 13p, 1 Chart
Abstrakt: The tert-butyl esters of 3-azidomethyl-, 3-isocyanatomethyl-, 3-chloromethyl-, and 3-p-nitrophenylvinyl-7α-chloro-1,1-dioxoceph-3-em-4-carboxylic acid, and also esters of 7α-chloro-3-methyl-1,1-dioxoceph-3-em-4-carboxylic acid, and of 7α-chloro-3-methyl-2-dimethylaminomethylene-1,1-dioxoceph-3-em-4-carboxylic acid have been synthesized. Results of cytotoxic screening of these compounds in relation to cancer and normal cells in vitro are correlated and analyzed. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index