| Autor: |
De Matos, Augusto José Ferreira, Lopes, Cé Cristina Carreiras, Faustino, Augusto Manuel Rodrigues, Carvalheira, Júlio Gil Vale, Rutteman, Gerard Roel, Gärtner, Maria de Fáima Rodrigues |
| Předmět: |
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| Zdroj: |
APMIS; Apr2007, Vol. 115 Issue 4, p327-334, 8p, 6 Color Photographs, 4 Charts |
| Abstrakt: |
Recent studies of canine malignant mammary tumours suggest that reduction of E-cadherin and/or β-catenin correlates with invasive behaviour and lymph node metastasis. The aims of this study were to examine the interrelationships between the expression of E-cadherin and β-catenin, and the relationship between the expression of E-cadherin and/or β-catenin and the mode of growth and metastatic capacity of canine malignant mammary tumours. 90 spontaneous malignant tumours and local and regional lymph nodes were studied. A significant relationship was evidenced between membranous expression of E-cadherin and β-catenin (p=0.0027), but not between E-cadherin and cytoplasmic β-catenin. Only E-cadherin as a separate factor was significantly related to tumour invasion (p=0.0072) and lymph node metastasis (p=0.0001). Neither membranous nor cytoplasmic β-catenin expression was significantly related to either of these phenomena. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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