Fibrillar and Oligomeric β-Amyloid as Distinct Local Biomarkers for Alzheimer's Disease.

Autor:	MONTALTO, MICHAEL C., FARRAR, GILL, HEHIR, CRISTINA TAN
Předmět:	ALZHEIMER'S disease NONINVASIVE diagnostic tests DIAGNOSTIC imaging PREVENTIVE medicine BIOMARKERS MENTAL health
Zdroj:	Annals of the New York Academy of Sciences; 2007, Vol. 1097, p239-258, 20p, 3 Diagrams, 1 Chart, 1 Graph
Abstrakt:	β-amyloid is a key component of Alzheimer's disease (AD) pathology. Researchers in both academic and industry are actively pursuing the development of imaging tracers and techniques to noninvasively measure local levels of β-amyloid in the Alzheimer's brain. This presentation summarizes recent data and discusses the opportunities and challenges of imaging plaques containing fibrillar β-amyloid for the early diagnosis and therapeutic monitoring of amyloid targeted therapies. Further, the value and feasibility of measuring the recently described soluble oligomeric form of β-amyloid as an alternative noninvasive biomarker is also discussed. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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