| Autor: |
Jones, H. M., Pilowsky, L. S. |
| Předmět: |
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| Zdroj: |
British Journal of Psychiatry; Oct2002, Vol. 181, p271-275, 5p, 1 Black and White Photograph |
| Abstrakt: |
The article discusses the dopamine hypothesis of antipsychotic drug action as well as review studies that have elaborated understanding of its relevance. The authors look into the dopaminergic pathways and receptor physiology and highlights that D2 receptors in schizophrenia were crucial to the genesis of the dopamine hypothesis. They also suggest that low-affinity drugs, with modest effects at D2 receptors, may antagonize the system in manner that preserves physiologically responsive endogenous dopamine transmission across a wide dose range. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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