| Autor: |
Hsia, Connie C. W., Johnson Jr., Robert L., McDonough, Paul, Dane, D. Merrill, Hurst, Myresa D., Fehmei, Jennifer L., Wagner, Harrieth E., Wagner, Peter D. |
| Předmět: |
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| Zdroj: |
Journal of Applied Physiology; Apr2007, Vol. 102 Issue 4, p1448-1455, 8p, 2 Charts, 5 Graphs |
| Abstrakt: |
Mammals native to high altitude (HA) exhibit larger lung volumes than their lowland counterparts. To test the hypothesis that adaptation induced by HA residence during somatic maturation improves pulmonary gas exchange in adulthood, male foxhounds born at sea level (SL) were raised at HA (3,800 m) from 2.5 to 7.5 mo of age and then returned to SL prior to somatic maturity while their littermates were simultaneously raised at SL. Following return to SL, all animals were trained to run on a treadmill; gas exchange and hemodynamics were measured 2.5 years later at rest and during exercise while breathing 21% and 13% O2. The multiple inert gas elimination technique was employed to estimate ventilation-perfusion (VA/Q) distributions and lung diffusing capacity for O2 (DLO2). There were no significant intergroup differences during exercise breathing 21% O2. During exercise breathing 13% O2, peak O2 uptake and VA/O distributions were similar between groups but arterial pH, base excess, and O2 saturation were higher while peak lactate concentration was lower in animals raised at HA than at SL. At a given exercise intensity, alveolar-arterial O2 tension gradient (A-aDO2) attributable to diffusion limitation was lower while DLO2 was 12-25% higher in HA-raised animals. Mean systemic arterial blood pressure was also lower in HA-raised animals; mean pulmonary arterial pressures were similar. We conclude that 5 mo of HA residence during maturation enhances long-term gas exchange efficiency and DLO2 without impacting VA/Q inequality during hypoxic exercise at SL. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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