Propranolol in chronic schizophrenia: a controlled study in neuroleptic-treated patients.
| Autor: | Lindström, Leif H., Persson, Eva, Lindström, L H, Persson, E |
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| Předmět: |
PROPRANOLOL
SCHIZOPHRENIA treatment NEUROLEPTIC malignant syndrome PEOPLE with schizophrenia SIDE effects of antipsychotic drugs PSYCHIATRIC rating scales DRUG therapy for schizophrenia ANTIPSYCHOTIC agents BLOOD pressure COMBINATION drug therapy CHRONIC diseases CLINICAL trials COMPARATIVE studies CONTROLLED release preparations DRUG synergism HEART beat RESEARCH methodology MEDICAL cooperation RESEARCH EVALUATION research BLIND experiment THERAPEUTICS |
| Zdroj: | British Journal of Psychiatry; Aug80, Vol. 137, p126-130, 5p, 2 Graphs |
| Abstrakt: | The effect of propranolol at a dose level of 1,280-1,920 mg per day was studied with a double-blind crossover design in twelve chronic schizophrenics with persistent psychotic symptoms despite maintenance treatment with a depot neuroleptic. By use of a psychiatric rating scale (CPRS), an improvement was seen during the two week period of propranolol compared to placebo treatment in six patients, whereas three patients were unchanged and three deteriorated. The effect on total symptom scores for the whole group was significantly better after propranolol. The data indicate that propranolol in high doses has an antipsychotic effect in some schizophrenic patients when receiving neuroleptics. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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