| Autor: |
Siever, Larry J., Insel, Thomas A., Jimerson, David C., Lake, C. Raymond, Uhde, Thomas W., Aloi, Joseph, Murphy, Dennis L., Siever, L J, Insel, T R, Jimerson, D C, Lake, C R, Uhde, T W, Aloi, J, Murphy, D L |
| Předmět: |
|
| Zdroj: |
British Journal of Psychiatry; Feb83, Vol. 142, p184-187, 4p |
| Abstrakt: |
We have observed a lesser growth hormone response to intravenous clonidine administration in nine obsessive-compulsive disorder patients meeting research diagnostic criteria than in nine matched controls. The obsessive-compulsive disorder patients had higher plasma free 3-methoxy-4-hydroxyphenylglycol and plasma norepinephrine levels before clonidine than the controls. As blunted growth hormone responses to clonidine are also characteristic of affective disorder patients, these results support other observations of a psychobiologic affinity between these two groups and are also compatible with an association between increased presynaptic noradrenergic activity and decreased post-synaptic receptor responsiveness. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
