Abrupt discontinuation of tricyclic antidepressant drugs: evidence for noradrenergic hyperactivity.

Autor:	Charney, Dennis S., Heninger, George R., Sternberg, David E., Landis, Harold, Charney, D S, Heninger, G R, Sternberg, D E, Landis, H
Předmět:	ANTIDEPRESSANTS HYPERKINESIA NORADRENALINE NEUROTRANSMITTERS ANXIETY GLYCOLS CLINICAL trials COMPARATIVE studies MENTAL depression DRUG withdrawal symptoms RESEARCH methodology MEDICAL cooperation RESEARCH EVALUATION research ETHYLENE glycols BLIND experiment
Zdroj:	British Journal of Psychiatry; Oct82, Vol. 141, p377-386, 10p, 2 Charts, 3 Graphs
Abstrakt:	The effect of abrupt discontinuation of amitriptyline, desipramine, or imipramine) on norepinephrine turnover and specific symptoms in seven depressed patients was examined. Turnover, as determined by plasma and urinary 3 methoxy-4-hydroxy-phenylethylene glycol (MHPG), was increased to a peak during the second week following discontinuation. There were no changes in blood pressure or heart rate. Two of the seven patients experienced clear increases in anxiety. The implications for the role of noradrenergic function is discussed. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu