Cognitive reduction in presenile dementia related to regional abnormalities of the cerebral blood flow.
| Autor: | Hagberg, Bo, Ingvar, David H., Hagberg, B O, Ingvar, D H |
|---|---|
| Předmět: |
PRESENILE dementia
BRAIN REGIONAL blood flow CEREBRAL cortex COGNITION OLDER people AGE distribution AGNOSIA BLOOD circulation CARBON dioxide COGNITION disorders DEMENTIA NEUROPSYCHOLOGICAL tests MEMORY disorders OCCIPITAL lobe PARIETAL lobe REACTION time SPACE perception SPEECH disorders TEMPORAL lobe PARTIAL pressure DISEASE complications |
| Zdroj: | British Journal of Psychiatry; Mar76, Vol. 128, p209-222, 14p, 2 Diagrams |
| Abstrakt: | Fifty-five patients with presenile dementia were examined. There were 28 women and 27 men, and the mean age was 59 and 56 years respectively at the time of the study. A large series of psychometric tests was used, and with the aid of age-matched non-demented controls five significantly different cognitive reduction groups could be identified. In the demented patients the regional cerebral blood flow (rCBF) was determined with an eight-detector or 32-detector equipment. There was a rough proportionality between the cognitive reduction and a decrease of the cerebral blood flow (especially the flow in the grey matter). In addition, certain regional flow abnormalities correlated with specific cognitive functions in a manner resembling the cognitive defects found in focal brain lesions in the same region. Thus, patients who showed only memory disturbances demonstrated a focal flow reduction in the temporal region. More severely affected patients, with reduction of verbal abilities and signs of agnosia, showed very low flows in occipito-temporo-parietal parts of the hemisphere. The results offer a principal confirmation of the dynamic field theory concerning the functional organization of the cerebral cortex. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
| Externí odkaz: |
|