The effect of parachlorophenylalanine on the sleep of a methadone addict.
| Autor: | Chernik, D. A., Ramsey, T. A., Mendels, J. |
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| Předmět: |
DRUG efficacy
MEDICAL research PEOPLE with heroin addiction SLEEP METHADONE treatment programs SEROTONIN antagonists NORADRENERGIC mechanisms DRUG abuse HEROIN abuse ACTION potentials ELECTROENCEPHALOGRAPHY ELECTROMYOGRAPHY ELECTROOCULOGRAPHY METHADONE hydrochloride PHENYLALANINE SEROTONIN SLEEP stages SUBSTANCE abuse TIME RAPID eye movement sleep INDOLE compounds |
| Zdroj: | British Journal of Psychiatry; Feb73, Vol. 122 Issue 567, p191-197, 7p, 1 Chart, 1 Graph |
| Abstrakt: | The article presents a study that determines the effects of parachlorophenylalanine (PCPA) on the sleep of a methadone addict. PCPA is a trytophan hydroxylase inhibitor which causes a major reduction in brain serotonin synthesis and levels, and slightly effects the brain norepinephrine metabolism. Researchers studied the effects of PCPA administration on the sleep of a 24-year-old male heroin addict who had been stabilized by methadone. They concluded that a significant increase in the delta wave sleep which coincides with urinary 5-hydroxyindoleacetic acid values leads them to speculate that there is a critical level of serotonin for optimal sleep and that levels of serotonin result to a decrease in delta sleep. |
| Databáze: | Complementary Index |
| Externí odkaz: |
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