Changes during weeks in effects of tricyclic drugs on the human sleeping brain.

Autor: Dunleavy, D. L. F., Brezinova, Vlasta, Oswald, Ian, Maclean, A. W., Tinker, M., Dunleavy, D L, Brezinova, V, Oswald, I
Předmět:
Zdroj: British Journal of Psychiatry; Jun72, Vol. 120 Issue 559, p663-672, 10p, 8 Graphs
Abstrakt: The article presents a study which investigates the physiological effects of tricyclic drugs on the human sleeping brain. Researchers use healthy young male adults as subjects who were given 75 milligram of the drug at 12 hours nightly for four weeks. The effects of tricyclic drugs such as imipramine, desipramine, chlorimipramine, doxepin, iprindole, and trimipramine were studied. Results reveal that some tricyclic drugs can have both of two types of effects on the human brain which include the independent duration of administration and the time-changing effect brought about by the slow modification of unknown cerebral components that have a life span of 3-4 weeks.
Databáze: Complementary Index