| Autor: |
Gong-Jun Yang, Xi-Long Qu, Ming Shen, Qi-Shu Qu, Chen-Ying Wang, Ai-Ping Zhu, Xiao-Ya Hu |
| Předmět: |
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| Zdroj: |
Journal of Fluorescence; Mar2007, Vol. 17 Issue 2, p119-126, 8p |
| Abstrakt: |
Abstract??It was found that in buffer solution of pH 7.0, the addition of sodium dodecyl sulfate (SDS) to the solution of phenothiazine drugs, such as chlorpromazine, promethazine and trifluoperazine, showed a remarkable enhancement of their fluorescence intensity. A further study proved that the phenothiazine drugs can be determined by fluorophotometric method in micellar system. Under optimal conditions, there was a good linear relationship between fluorescence intensity and phenothiazine compounds concentration, and the detection limit of 3.0?10-8?M chlorpromazine, 3.0?10?8?M promethazine and 1.5?10?8?M trifluoperazine (S/N=3) were also obtained. This method has been used to determine phenothiazine drugs in tablets with satisfactory results. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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