Role of γ-Aminobutyric Acid in Antipanic Drug Efficacy.

Autor:	Breslow, Michael F., Fankhauser, Martha P., Potter, Rebecca L., Meredith, Keith E., Misiaszek, John, Hope, Jr., Deane G.
Předmět:	DRUG efficacy PANIC attacks AMINOBUTYRIC acid AMINO acid neurotransmitters DRUG development GABA receptors ANXIETY testing PATHOLOGICAL psychology
Zdroj:	American Journal of Psychiatry; Mar89, Vol. 146 Issue 3, p353-356, 4p
Abstrakt:	All effective pharmacologic agents used to treat panic disorder augment γ-aminobutyric acid (GABA) transmission. Anxiolytics and antidepressants that lack GABA activity are not effective in panic disorder. To test the hypothesis that GABA activity is a component of antipanic drug efficacy, the authors treated nine medication-free panic disorder subjects with oral baclofen (30 mg/day for 4 weeks) in a double-blind, placebo-controlled crossover trial. Baclofen, a selective GABA agonist, was significantly more effective than placebo in reducing the number of panic attacks and scores on the Hamilton anxiety scale, Zung scale, and Katz-R nervousness subscale. The authors discuss possible mechanisms of antipanic drug efficacy. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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