| Autor: |
Souêtre, Eric, Salvati, Edouard, Krebs, Bernard, Belugou, Jean-Luc, Darcourt, Guy |
| Předmět: |
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| Zdroj: |
American Journal of Psychiatry; Aug89, Vol. 146 Issue 8, p1037-1040, 4p, 1 Chart, 1 Graph |
| Abstrakt: |
The authors investigated the melatonin response to 5-methoxypsoralen in 39 healthy adult and elderly subjects and in 13 demented, 13 depressed, and 13 schizophrenic in patients. Subjects' plasma melatonin levels were evaluated before they took single, oral 40-mg doses of 5-methoxypsoralen and 3 hours afterward. The preliminary results indicate that the melatonin response of the pineal gland to 5-methoxypsoralen is reduced in demented patients compared to that in healthy elderly subjects. Depressed and schizophrenic patients had a normal melatonin response to the drug. This finding suggests that the pineal gland may be functionally impaired in dementia but not in depression. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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