| Autor: |
Rabkin, Judith G., McGrath, Patrick J., Quitkin, Frederic M., Tricamo, Elaine, Stewart, Jonathan W., Klein, Donald F. |
| Předmět: |
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| Zdroj: |
American Journal of Psychiatry; Dec90, Vol. 147 Issue 12, p1622-1626, 5p |
| Abstrakt: |
Fifty outpatients with mild, chronic, mood-reactive depression whose mood improved markedly after a 10-day single-blind placebo trial were randomly assigned in a double-blind design either to have their placebo medication discontinued or to have it maintained for an additional 6 weeks. Half of the patients in each condition relapsed within 6 weeks, indicating that pill-taking itself does not influence maintenance of placebo response. Placebo response was more likely to be maintained in patients who were currently married. At the end of 3 months, the overall relapse rate was 58%. The authors raise questions about the utility of the initial 10-day placebo washout in antidepressant clinical trials, and they discuss limits on the generalizability of their findings. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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