Stereoselective synthesis and neurotropic activity of phosphorylacetic acid derivatives.

Autor: Tarasova, R., Voskresenskaya, O., Eliseenkova, R., Semina, I., Shilovskaya, E., Latypov, Sh., Balandina, A., Bredikhin, A.
Předmět:
Zdroj: Pharmaceutical Chemistry Journal; Sep2006, Vol. 40 Issue 9, p469-472, 4p
Abstrakt: Stereoselective synthesis of an optically active menthyl ester of 2-chloroethoxy-4′-dimethylaminophenylphosphorylacetic acid (CAPAM) is described. The product structure was confirmed by elemental analyses and IR, NMR (1H, 13C, 31P), and mass spectroscopy measurements. When tested for neuropharmacological properties, CAPAM exhibited a neurotropic (deprivating) activity and myorelaxant action. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index