Phosphodiesterase inhibitors prevent NSAID enteropathy independently of effects on TNF-... release.

Autor: Reuter, Brian K., Wallace, John L.
Předmět:
Zdroj: American Journal of Physiology: Gastrointestinal & Liver Physiology; Oct1999, Vol. 277 Issue 4, pG847, 8p, 9 Graphs
Abstrakt: Explores the role of tumor necrosis factor (TNF)-alpha in mediating nonsteroidal anti-inflammatory drugs-induced small intestinal injury. Bile and tissue levels of TNF-alpha; Small intestinal tissue TNF-alpha messenger RNA expression; Inhibition of TNF-alpha synthesis/release; Biliary excretion of diclofenac.
Databáze: Complementary Index