| Autor: |
Huolin Tu, Peter Rady, Terry Juelich, Stephen Tyring, Nina Koldzic-Zivanovic, Thomas Hughes |
| Předmět: |
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| Zdroj: |
Cellular & Molecular Neurobiology; Mar2007, Vol. 27 Issue 2, p161-170, 10p |
| Abstrakt: |
??1.Aim: The hypothalamic-pituitary-adrenal (HPA) axis is a mediator for interactions between the immune and neuroendocrine systems. Pro-inflammatory cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-?) have been shown to activate the HPA axis. Recently, interleukin-10, an important anti-inflammatory cytokine in the immune system, has been shown to be expressed in the central nervous system and neuroendocrine system. Little is known, however, about IL-10?s functions in the HPA axis.2.Methods: The Affymetrix DNA microarray (mouse genome U74Av2 Probe Array) was conducted to determine the gene expression profile regulated by IL-10 in cells of HPA axis origin.3.Results: In this study, we analyzed gene expression regulated by IL-10 in cells derived from the HPA axis. The results showed that quorums of genes are modulated by IL-10 in these neuroendocrine cells.4.Conclusions: These findings will provide a valuable repository to aid in understanding IL-10?s functions in the HPA axis at the molecular level. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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