| Autor: |
Chung Fang Lai, Su-Li Cheng, Mbalaviele, Gabriel, Donsante, Christine, Watkins, Marcus, Radice, Glenn L., Civitelli, Roberto |
| Zdroj: |
Journal of Bone & Mineral Research; Dec2006, Vol. 21 Issue 12, p1897-1906, 10p, 4 Diagrams, 2 Charts, 3 Graphs |
| Abstrakt: |
The article provides evidence that N-cadherin (Cdh2) modulates osteogenic differentiation and bone formation. Ovarietomy-induced bone loss is accentuated in mice with germline Cdh2 haploinsufficiency, the result of a decreased osteoblastogenesis in the face of normal osteoclast number. Reduced Cdh2 abundance in the mice decreases cell-cell adhesion and alters signaling pathways important for osteoblast commitment and differentiation. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text