| Autor: |
Cheng Wang, Zi-li You, Qing Xia, Tao Xiong, Yang Xia, De-zhong Yao |
| Předmět: |
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| Zdroj: |
Acta Pharmacologica Sinica; Mar2007, Vol. 28 Issue 3, p334-338, 5p, 1 Black and White Photograph, 2 Charts, 2 Graphs |
| Abstrakt: |
Aim: To investigate the effect of jujuboside A (JuA) on modulating gene expression in the hippocampus. Methods: The spontaneous activity of mice was monitored, and the differential display polymerase chain reaction was adapted to screen differentially-expressed genes modulated by JuA in the mouse hippocampus. Results: JuA significantly decreased the total activity intensity ( P < 0.01 vs control) at a dosage of 80 mg/kg, and the genes MAP/microtubule affinity-regulating kinase3 (Mark3) and retinitis pigmentosa GTPase regulator interacting protein 1 (Rpgrip1) were upregulated by JuA in the mouse hippocampus. Conclusion: JuA had an inhibitory effect on the spontaneous activity of the mice, and JuA regulated the transcription of Mark3 and Rpgrip1 in the mouse hippocampus. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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