| Autor: |
DONNA CULTON, MATILDA NICHOLAS, DONNA BUNCH, QUAN ZHEN, THOMAS KEPLER, MARY DOOLEY, CHANDRA MOHAN, PATRICK NACHMAN |
| Předmět: |
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| Zdroj: |
Journal of Clinical Immunology; Jan2007, Vol. 27 Issue 1, p53-68, 16p |
| Abstrakt: |
???We report here that dysregulation of CD19, a coreceptor that augments B-cell receptor (BCR) signaling, occurs at two B-cell differentiative stages in patients with systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic autoantibody (ANCA) associated small vessel vasculitis (SVV). The na?ve B cells of nearly all SLE and ANCA-SVV patients express ?20% less CD19 than healthy control (HC) B cells. In contrast, a subset of memory B cells of some SLE and ANCA-SVV Pts (25?35%) express two to fourfold more CD19 than HC B cells. These CD19himemory B cells are activated and exhibit evidence of antigen selection. Proteome array analysis of 67 autoantigens indicates that CD19hiSLE Pts exhibit a distinct autoantibody profile characterized by high levels of antibodies to small nuclear ribonucleoproteins and low levels of antiglomerular autoantibodies. These findings have implications for autoreactive B-cell activation and suggest a shared mechanism of B-cell tolerance loss in these two diseases. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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