| Autor: |
Guang-Su Xiong, Shu-Ming Wu, Zhen-Hua Wang, Jian-Zhong Mo, Shu-Dong Xiao |
| Předmět: |
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| Zdroj: |
Journal of Gastroenterology & Hepatology; Mar2007, Vol. 22 Issue 3, p371-376, 6p, 1 Chart, 3 Graphs |
| Abstrakt: |
Background: Tumor necrosis factor-α (TNF-α) plays a central role in the pathogenesis of acute pancreatitis and related systemic complications. The authors hypothesized that it may also play an important role in the development of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). The aim of the study was to evaluate the effectiveness of thalidomide, an immunomodulator that exerts an inhibitory action on TNF-α by enhancing mRNA degradation, in reducing post-ERCP pancreatitis in a rat model. Methods: A total of 200 mg/kg thalidomide was given intragastric once a day (total 8 days) before the experimental models of post-ERCP pancreatitis were established. After 24 h, histology and edema of pancreas, serum amylase, and TNF-α mRNA in the pancreatic tissue were evaluated. Results: Intraductal contrast infusion caused increases in serum amylase, edema, histological grade, and TNF-α mRNA of pancreas. The prophylactic use of thalidomide significantly reduced serum amylase, pancreatic edema and the histologic grade of pancreatitis accompanied by a decrease in mRNA expression of TNF-α in the pancreatic tissue. Conclusions: Prophylactic intragastric administration of thalidomide provides a protective effect in post-ERCP pancreatitis. The mechanism of the protective effects of thalidomide seems to be the reduction of expression of TNF-α mRNA in pancreatic tissue. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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