| Autor: |
Thum, Meen-Yau, Abdalla, Hossam I., Bhaskaran, Shree, Harden, Emily L., Ford, Brian, Sumar, Nazira, Shehata, Hassan, Bansal, Amolak |
| Předmět: |
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| Zdroj: |
American Journal of Reproductive Immunology; Mar2007, Vol. 57 Issue 3, p210-217, 8p, 5 Charts |
| Abstrakt: |
Background To evaluate the association of serum tumour necrotic factor (TNF)- α and interferon (IFN)- γ levels with IVF treatment outcome and peripheral blood NK cells. Methods Prospective observational study of 126 randomly selected women who underwent IVF treatment. The serum levels of TNF- α and IFN- γ were determined by multiplex suspension beads array system. Results There were no significant differences with regard to the systemic TNF- α and IFN- γ levels between the pregnant ( n = 51, TNF- α: 53.5 pg/mL; IFN- γ: 4.6 pg/mL) and not pregnant ( n = 75, TNF- α: 63.0; IFN- γ: 7.5) women after IVF treatment. For those women with a positive pregnancy after IVF treatment, the systemic TNF- α and IFN- γ levels were higher in those women who miscarried ( n = 13, TNF- α: 67.4; IFN- γ: 9.1) when compared with those who had a live birth ( n = 38, TNF- α: 48.7; IFN- γ: 1.4), however this difference was not statistically significant. Interestingly, the systemic TNF- α and IFN- γ levels were significantly higher in women who had a higher level of activated (CD69+) NK cells ( n = 39, TNF- α: 86.8; IFN- γ: 4.7) when compared with women who had a low level of activated NK cells ( n = 87, TNF- α: 46.9; IFN- γ: 1.7 P = 0.028 and 0.045 respectively). Conclusion The systemic levels of TNF- α and IFN- γ have no association with implantation rate or miscarriage rate in women undergoing IVF treatment. However, high levels of TNF- α and IFN- γ are associated with elevated levels of activated NK cells and this may subsequently exert a negative impact on reproduction. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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