| Autor: |
Dummer, Reinhard, Cozzio, Antonio, Meier, Sibylle, Beyeler, Mirjam, Laetsch, Barbara, Doebbeling, Udo, Urosevic, Mirjana |
| Předmět: |
|
| Zdroj: |
Journal of Cutaneous Pathology; Feb2006 Supplement, Vol. 33, p52-57, 6p |
| Abstrakt: |
Cutaneous T-cell lymphomas are a heterogeneous group of lymphoproliferative disorders, characterized by the accumulation of clonal lymphocytes in the skin. Skin-directed therapies are the preferred first-line modalities. There are interesting new developments in topical therapy using retinoids and gene-therapy products such as adenovirusinterferon (IFN)-γ. Systemic treatment uses biologicals such as fusion molecules, monoclonal antibodies and immune response modifiers (IFNs and retinoids), and well-tolerated antiproliferative drugs such as methotrexate. Evidence-based treatment recommendation exists but is hampered by the lack of large multicenter randomized trials. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
