REDUCTIONS IN A KEY MITOCHONDRIAL ENZYME IN BRAINS FROM ALZHEIMER'S DISEASE PATIENTS CORRELATE WITH A CLINICAL DEMENTIA RATING.

Autor: Gibson, G. E., Haroutunian, V., Park, L. C. H., Zhang, H., Mohs, R., Sheu, R. K. F., Blass, J. P.
Předmět:
Zdroj: Journal of Neurochemistry; Jul99 Supplement, Vol. 73, pS23-S23, 1/4p
Abstrakt: The article presents an abstract of the research paper "Reductions in a Key Mitochondrial Enzyme in Brains From Alzheimer's Disease Patients Correlate With a Clinical Dementia Rating." The findings of the study provide evidence that the reduction in α-ketoglutarate dehydrogenase complex in Alzheimer's disease brain is a critical component of a cascade of events that lead to neurodegeneration.
Databáze: Complementary Index