Synthesis and antiarrhythmic properties of N-acylamino derivatives of 1,6,7-substituted 1,2,3,4-tetrahydroisoquinoline-4-spirocyclopentanes and their analogs.

Autor:	Markaryan, É. A., Arustamyan, Zh. S., Avetisyan, S. V., Markaryan, R. É., Markaryan, K. Zh., Asatryan, T. O., Grigoryan, A. V.
Předmět:	PIPERIDINE MYOCARDIAL depressants CARDIOVASCULAR agents PHARMACEUTICAL research PHARMACEUTICAL chemistry ACIDS
Zdroj:	Pharmaceutical Chemistry Journal; Jul2006, Vol. 40 Issue 7, p360-362, 3p
Abstrakt:	Aseries of new N-chloracetyl derivatives have been synthesized proceeding from 4-spirocyclopentane-substituted 1,2,3,4-tetrahydroisoquinolines, 1-phenyl-1-cyclopentylmethylamine, and chloroanhydrides of bromoacetic and α-bromopropionic acids. Reactions of these bromoamides with amines (piperidine, morpholine) yield the title N-acylamino derivatives. The antiarrhythmic properties of the synthesized compounds have been studied. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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