| Autor: |
Langer, Jessica C., Kumar, Ritu, Snoeck, Hans-Willem |
| Předmět: |
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| Zdroj: |
Journals of Gerontology Series A: Biological Sciences & Medical Sciences; Jun2006, Vol. 61 Issue 6, p568-571, 4p, 2 Graphs |
| Abstrakt: |
We discovered a novel population of γδ, T cells in the mouse that accumulates with age in hematopoietic organs, but not in epithelia. These cells are CD25low (an unusual phenotype for y6 T cells in the mouse); express higher levels of TCRγδ and CD44 than do CD25- γδ T cells; mainly express Vγ2, Vγ3, and Vγ4 chains; and are largely quiescent. A very similar cell population appears in the late stages of fetal thymus organ cultures, suggesting that the accumulation of CD44+CD25lowTCRTγδ+ cells is a response to stress induced by aging in vivo or by culture in vitro. The precursors of CD44+CD25lowTCRγδ+ cells are generated during fetal or very young adult life, as this population was undetectable in aged recipients of bone marrow from old or young donors. CD44+CD25lowTCRγδ+ cells may be a biomarker of aging, but could also play a role in the inflammatory changes that accompany aging. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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