| Autor: |
Dressel, A., Kolb, A. K., Elitok, E., Bitsch, A., Bogumil, T., Kitze, B., Tumani, H., Weber, F. |
| Předmět: |
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| Zdroj: |
Acta Neurologica Scandinavica; Dec2006, Vol. 114 Issue 6, p368-373, 6p, 3 Color Photographs, 2 Charts |
| Abstrakt: |
Objectives – It is unknown whether the immunological effects of β-interferon (IFN- β) differ in primary progressive multiple sclerosis (PPMS) when compared with relapsing–remitting multiple sclerosis (RRMS). Therefore, we investigated the effects of IFN- β1b treatment in PPMS on proliferation and cytokine pattern of peripheral blood mononuclear cells (PBMC) and interleukin-10 (IL-10) serum level. Methods – Eighteen patients were treated with IFN- β1b for 12 months in an open-label trial. Serum and PBMC were collected longitudinally. Results – Interleukin-10 serum levels increased ( P = 0.02) during treatment. Tumor necrosis factor- α was increased in anti CD3 (OKT3) antibody stimulated PBMC during treatment ( P = 0.04), whereas secretion of IL-10 was decreased in OKT3 ( P = 0.04), but increased in concavalin A stimulated PBMC ( P = 0.02). Conclusions – Interleukin-10 serum levels rose in IFN- β1b-treated patients as has been observed in RRMS. The changes in cytokine patterns secreted by T-lymphocytes of PPMS patients, however, differ from effects observed in RRMS supporting the hypothesis that PPMS differs in some immunological aspects from RRMS. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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