| Autor: |
Taléns-Visconti, Raquel, Rivera Otero, Miguel, Sancho-Tello, José, de Burgos, Fernando García, Martínez-Dolz, Luis, Sevilla, Begoña, Climent, Vicente, Cortés, Raquel, Salvador, Antonio, Sogorb, Francisco, Miro, Vicente, Valero, Ricardo, Perez-Boscá, Jose Luis, Bertomeu, Vicente, Portolés, Manuel, Payá, Rafael |
| Zdroj: |
European Journal of Echocardiography; Jan2006, Vol. 7 Issue 1, p45-52, 8p |
| Abstrakt: |
Abstract: Aims: N-terminal pro-brain natriuretic peptide (NT-proBNP) is useful in the diagnosis of heart failure (HF). LV two-dimensional cavity area from end-diastole (LVEDA) and end-systole (LVESA), and LV fractional area change (LVFAC) reflect changes in LV morphology and function without using geometric assumptions. In a multicenter study, we correlated LVEDA, LVESA and LVFAC with NT-proBNP, comparing patients with dilated and ischemic cardiomyopathy. Methods and results: We studied 106 HF patients. In the dilated group, NT-proBNP correlated with LVEDAI (r =0.6), LVESAI (r =0.7) and LVFAC (r =−0.6), all significant at p <0.001. In patients with ischemic cardiomyopathy we found LVESAI (r =0.3, p <0.05) and LVFAC (r =−0.4, p <0.01). After adjustment for age and BMI, LVFAC and LVESAI were associated in a multiple linear regression analysis with peptide levels (adjusted r 2 =0.5, p <0.001). Conclusions: In this study we found a good correlation of NT-proBNP with LV cavity areas and LVFAC. Multiple regression analysis showed that when adjusted for age and BMI, LVFAC and LVESAI are independent predictors of NT-proBNP levels in both dilated and ischemic etiologies. Patients with dilated cardiomyopathy showed better results than those with ischemic cardiomyopathy. We think LV areas are a useful and reproducible parameter, do not need geometric assumptions and reflect NT-proBNP plasma levels. [Copyright &y& Elsevier] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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