| Autor: |
Gaia, Silvia, Cappia, Susanna, Smedile, Antonina, Bacillo, Elisa, Gaia, Ezio, Gubetta, Luciano, Rizzetto, Mario |
| Předmět: |
|
| Zdroj: |
Journal of Gastroenterology & Hepatology; Dec2006, Vol. 21 Issue 12, p1801-1806, 6p, 1 Diagram, 3 Charts |
| Abstrakt: |
Background: Eleven liver biopsies from six male patients who received a liver transplant (LT) from female donors were examined in order to determine whether male host-derived hepatic cells were present in female grafts that exhibited minimal or important inflammatory damage. Methods: Immunohistochemistry for epithelial cell type differentiation (anticytokeratin monoclonal antibody) and fluorescence in situ hybridization for XY chromosomes identification were performed on each slide. Results: Host-derived hepatic cells were found in all except one transplant, with a frequency ranging from 2.3 to 25‰ of the total hepatocytes in the biopsy specimen. They were usually found as isolated cells scattered throughout the hepatic lobule; in one patient they were grouped into little clusters. Host-derived hepatic cells persisted throughout the histological follow up (up to 535 days after LT). Polyploidy for XY chromosome was observed. Conclusion: Hepatocytes derived from extra-hepatic stem cells are frequently found in small numbers in human liver grafts and persist over time. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text