| Autor: |
Rodrigue, Sébastien, Provvedi, Roberta, Jacques, Pierre-Étienne, Gaudreau, Luc, Manganelli, Riccardo |
| Předmět: |
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| Zdroj: |
FEMS Microbiology Reviews; Nov2006, Vol. 30 Issue 6, p926-941, 16p, 3 Diagrams, 2 Graphs |
| Abstrakt: |
Mycobacterium tuberculosis is a remarkable pathogen capable of adapting and surviving in various harsh conditions. Correct gene expression regulation is essential for the success of this process. The reversible association of different σ factors is a common mechanism for reprogramming bacterial RNA polymerase and modulating the transcription of numerous genes. Thirteen putative σ factors are encoded in the M. tuberculosis genome, several being important for virulence. Here, we analyse the latest information available on mycobacterial σ factors and discuss their roles in the physiology and virulence of M. tuberculosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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