| Autor: |
Hassan, Rocío, Franco, Sergio A. L., Stefanoff, Claudio Gustavo, Romano, Sergio O., Diamond, Hilda R., Franco, Luiz G. P., Seuánez, Héctor N., Zalcberg, Ilana R. |
| Předmět: |
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| Zdroj: |
Pathology International; Nov2006, Vol. 56 Issue 11, p668-673, 6p, 1 Diagram, 1 Chart, 1 Graph |
| Abstrakt: |
Hepatosplenic γδ T-cell lymphoma (HSTL) is a clinicopathological entity associated with an immunocompromised status in approximately 25% of patients. Herein is described a case of HSTL in a 53-year-old Brazilian man with seven previous malaria infections, initially misdiagnosed as a hyperreactive splenomegaly due to chronic malaria. A characteristic lymphoid infiltrate was observed in spleen, liver and bone marrow sinusoids/sinuses. Neoplastic cells had a CD45RO+, CD2+, CD7+, CD3+, CD5–, CD8+, CD56+, perforin+, FasL-negative, T-cell receptor (TCR)αβ-negative, TCRγδ+ profile. Analyses of γ and δ TCR rearrangements confirmed diagnosis of γδ T-cell lymphoma by detecting VγI/Vδ1-Jδ1 clonal rearrangements. Sensitive polymerase chain reaction (PCR) for Plasmodium falciparum, Epstein–Barr virus and herpesvirus-8 failed to demonstrate infection. The disease progressed to a fatal outcome following cutaneous infiltration and leukemic proliferation. The authors also comment on the association of lymphoma and infection, focusing on PCR diagnosis of TCRγ and δ clonal rearrangements and the presumed pathogenic events leading to HSTL in the context of chronic malaria infection. Initial lymphomagenic stages might not be direct consequences of antigenic stimulation of Vδ1 T-cells, but might depend on interactions between γδ T and B cells during cooperative or regulatory responses to Plasmodium sp. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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