| Autor: |
Hollingsworth, S. J., Powell, G. L., Barker, S. G. E |
| Předmět: |
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| Zdroj: |
Phlebology; 2005, Vol. 20 Issue 3, p117-122, 6p, 1 Graph |
| Abstrakt: |
Objectives: To examine plasma soluble flt-1 (s.flt-1) and its release in primary varicose (VVs) and normal veins. Methods: Patients with primary VVs (n = 13, CEAP grade II or above) and control subjects (n = 7) (all non-smokers, receiving no medications) rested supine for 15 min before cannulation of a foot vein. Following a further 10 min resting supine, blood was collected from an arm vein and foot vein. A below-knee cuff was applied and inflated to 90–95 mmHg for 10 min (to prompt a mild venous stasis). A further blood sample was collected from the foot vein. Plasma s.flt-1 was analysed by ELISA. Results: Baseline plasma s.flt-1 from the arm was similar in normal subjects and patients with VVs (P>0.1). From the foot before cuff application, however, baseline plasma s.flt-1 was markedly elevated in VVs (P<0.001). Application of the cuff in control subjects resulted in a marked (54.2%) elevation in s.flt-1 by 10 min (P<0.015). In VVs, however, cuff application prompted little or no change, an increase of only 5.5% (P>0.1). Conclusions: Elevated plasma levels of s.flt-1 may be important in the pathogenesis of primary VVs, by potentially mediating the action(s) of vascular endothelial growth factor. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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