Clues to VIP Function from Knockout Mice.

Autor:	HAMIDI, S.A., SZEMA, A.M., LYUBSKY, S., DICKMAN, K.G., DEGENE, A., MATHEW, S.M., WASCHEK, J.A., SAID, S.I.
Předmět:	MICE VASOACTIVE intestinal peptide ASTHMA GASTROINTESTINAL hormones NEUROTRANSMITTERS
Zdroj:	Annals of the New York Academy of Sciences; 2006, Vol. 1070 Issue 1, p5-9, 5p, 3 Graphs
Abstrakt:	We have taken advantage of the availability of vasoactive intestinal polypeptide (VIP) knockout (KO) mice to examine the possible influence of deletion of the VIP gene on: ( a) airway reactivity and airway inflammation, as indicators of bronchial asthma; ( b) mortality from endotoxemia, a model of septic shock; and ( c) the pulmonary circulation. VIP KO mice showed: ( a) airway hyperresponsiveness to the cholinergic agonist methacholine, as well as peribronchial and perivascular inflammation; ( b) a greater susceptibility to death from endotoxemia; and ( c) evidence suggestive of pulmonary hypertension. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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