Transient K+ Current is Blocked by Lanthanum in Drosophila Neurons.

Autor: Waleed Alshuaib, Mini Mathew
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Zdroj: Neurochemical Research; Sep2005, Vol. 30 Issue 9, p1087-1092, 6p
Abstrakt: The potassium A-current (IKA) is important in regulating the membrane potential between action potentials. The whole-cell patch-clamp technique was applied to cultured Drosophila neurons derived from embryonic neuroblasts. IKA was measured from neurons before and after application of 0.1 mM lanthanum to the external saline. IKA was smaller in the lanthanum-containing saline (7±1 pA) than in the control saline (34±6 pA). Activation and inactivation of IKA were unchanged by lanthanum. These results suggest that lanthanum neurotoxicity may lead to increased neuronal excitability. Moreover, given this inhibition of IKA, lanthanum should not be used to block calcium current in studies of K+ currents. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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