| Autor: |
De Rooij, Susanne R., Painter, Rebecca C., Bossuyt, Patrick M. M., Roseboom, Tessa J., Phillips, David I. W., Osmond, Clive, Michels, Robert P. J., Godsland, Ian F., Bleker, Otto P. |
| Předmět: |
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| Zdroj: |
Diabetes Care; Aug2006, Vol. 29 Issue 8, p1897-1901, 5p, 2 Charts, 1 Graph |
| Abstrakt: |
OBJECTIVE -- We previously reported that people prenatally exposed to famine during the Dutch Hunger Winter of 1944-1945 have higher 2-h glucose concentrations after an oral glucose tolerance test in later life. We aimed to determine whether this association is mediated through alterations in insulin secretion, insulin sensitivity, or a combination of both. RESEARCH DESIGN AND METHODS -- We performed a 15-sample intravenous glucose tolerance test in a subsample of 94 normoglycemic men and women from the Dutch Famine Birth Cohort. We used the disposition index, derived as the product of insulin sensitivity and the first-phase insulin response to glucose as a measure of the activity of the β-cells adjusted for insulin resistance. In all analyses, we adjusted for sex and BMI. RESULTS -- Glucose tolerance was impaired in people who had been prenatally exposed to famine compared with people unexposed to famine (difference in intravenous glucose tolerance test K[sub g] value -21% [95% C1 -41 to -41). People exposed to famine during midgestation had a significantly lower disposition index (-53% [-126 to -31) compared with people unexposed to famine. Prenatal exposure to famine during early gestation was also associated with a lower disposition index, but this difference did not reach statistical significance. CONCLUSIONS -- Impaired glucose tolerance after exposure to famine during midgestation and early gestation seems to be mediated through an insulin secretion defect. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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