A Simple Method for Preparation of 18α-Glycyrrhetinic Acid and Its Derivatives.

Autor: D. V. Ignatov, Yu. I. Prokof'ev, O. M. Ipatova, V. P. Timofeev, N. V. Medvedeva, A. Yu. Misharin
Zdroj: Russian Journal of Bioorganic Chemistry; Jul2003, Vol. 29 Issue 4, p390-394, 5p
Abstrakt: Treatment of 18β-glycyrrhizic acid with a methanolic solution of HCl resulted in 1 : 1 mixture of methyl esters of 18α- and 18β-glycyrrhetinic acids. Benzoylation of the mixture led to methyl esters of 3-benzoyl-18α-glycyrrhetinic acid and 3-benzoyl-18β-glycyrrhetinic acid, which were separated by chromatography on silica gel. 18α-Glycyrrhetinic acid was prepared by alkaline hydrolysis of methyl 3-benzoyl-18α-glycyrrhetinate and was further used for the syntheses of 3-keto-18α-glycyrrhetinic acid and methyl esters of 18α-glycyrrhetinic acid and 3-keto-18α-glycyrrhetinic acid. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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