| Autor: |
Kozlov, J. V., Sudarkina, O. J., Kurmanova, A. G. |
| Předmět: |
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| Zdroj: |
Molecular Biology; Jul2006, Vol. 40 Issue 4, p635-646, 12p, 4 Diagrams |
| Abstrakt: |
A heterogeneous group of plant proteins are capable of enzymatically inactivating ribosomes by depurination of the invariant adenine in the 28S rRNA. Some of these proteins are heterodimers, containing a lectin subunit joined to an enzymatic subunit via a disulfide bond. Ricin and abrin, which are among the most toxic substances known, belong to this class of heterodimeric proteins. The review focuses on the structure of plant heterodimeric ribosome-inactivating proteins, the way of their action on the ribosome, biosynthesis, intracellular trafficking, and potential applications in medicine. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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