| Autor: |
Katz, Bradley A., Clark, James M., Finer-Moore, Janet S., Jenkins, Thomas E., Johnson, Charles R., Ross, Michael J., Luong, Christine, Moore, William R., Stroud, Robert M. |
| Předmět: |
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| Zdroj: |
Nature; 2/5/1998, Vol. 391 Issue 6667, p608, 5p, 2 Color Photographs, 1 Diagram, 2 Charts |
| Abstrakt: |
Reports a mode of high-affinity binding in which a zinc2+ ion is tetrahedrally coordinated between two chelating nitrogens of BABIM and two active site residues, His 57 and Ser 195. What is implied by the distinct Zn2+ coordination geometry; The suggestion that small molecule inhibitors of serine proteases with high affinity could be used as scaffolds from which to develop drugs selective for protease targets; Methods. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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