| Abstrakt: |
The uterine cellular expression and distribution of c-fos, ERα and p38α was compared in humans, nonhuman primates, and rats using immunohistochemistry.ERα and c-fos were present in the glandular (GE) and luminal epithelial cells (LE) of humans and nonhuman primates, with differing expression patterns evident between proliferative and secretory cycle phases. In rats, the highest and lowest expression of c-fos was present during proestrus and estrus, respectively, in the LE and GE. The most intense ERα staining in rats was observed during proestrus in the GE, while the least intense staining was seen in the LE during proestrus. Strong LE and GE expression of p38α was present in rats in all stages of the estrous cycle and during the proliferative phase in both humans and nonhuman primates. No p38α expression was observed during the secretory phase in either humans or nonhuman primates. Our work suggests that c-fos, ERα and p38α (a) are primarily expressed during the proliferative phase, but not the secretory phase and exhibit interspecies expression variability, and (b) rats exhibit cyclic changes in the expression of c-fos and ERα. [ABSTRACT FROM AUTHOR] |
