Efficient expression of a transgene in platelets using simian immunodeficiency virus-based vector harboring glycoprotein Ibα promoter: in vivo model for platelet-targeting gene therapy.

Autor:	Ohmori, Tsukasa, Mimuro, Jun, Takano, Katsuhiro, Madoiwa, Seiji, Kashiwakura, Yuji, Ishiwata, Malta, Niimura, Masanori, Mitomo, Katsuyuki, Tabata, Toshiaki, Hasegawa, Mamoru, Ozawa, Keiya, Sakata, Yoichi
Předmět:	TRANSGENE expression BLOOD platelets GENE therapy HEMOPHILIA BLOOD diseases
Zdroj:	FASEB Journal; Jul2006, Vol. 20 Issue 9, p1522-1524, 3p, 1 Diagram, 2 Graphs
Abstrakt:	Develops a technique for efficient transgene expression in platelets in vivo and examines whether this targeted-gene-product delivery system using the platelet release reaction was directly applicable to gene therapy for coagulation deficiency hemophilia A. Comparison of luciferase reporter expression driven by platelet-specific promoters; Life span of megakaryocytes; Description of hemophilia A.
Databáze:	Complementary Index
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